Objective: To examine the neuroprotective effects of Cassia angustifolia using behavioural memory tests and to estimate the biochemical parameters using brain homogenate. To examine the protective role of Cassia angustifolia ethanolic leaf extract in colchicine-induced cognitive dysfunction and oxidative damage in Swiss albino mice. Methods: For a total of 28 days (4 weeks), a colchicine-induced model was used for the study. Utilizing the elevated plus maze, passive avoidance paradigm, morris water maze and actophotometer for behavioural studies, acetyl cholinesterase (AChE), total protein, lipid peroxidation (MDA), and glutathione (GSH) levels in brain homogenate were calculated. Eight groups of six Swiss albino mice each were created from the 48 total. Carboxymethylcellulose, 1% w/v, was given to class I. Group II piracetam was administered i.p. (200 milligrams / kg). Group III obtained 1 mg / kg of colchicine i.c.v. Group IV and V were provided with 400 and 800 mg / kg of ethanolic Cassia angustifolia leaf extract. Group VI was administered Piracetam (200 mg / kg, i.p.) to mice for 28 consecutive days. Colchicine 1 mg / kg, i.p., at 60 min after 28th day piracetam injection was injected. Group VII and VIII received 400 and 800 mg / kg oral ethanolic Cassia angustifolia leaf extract for 28 consecutive days, and colchicine (1 mg / kg) was injected i.c.v at 90 min after administration of extract on 28th day. All the data were analyzed using One-way ANOVA followed by a check by Tukey’s test.