Fluoride is a neurotoxic element that causes damage to neural tissue by crossing the cell membrane and blood-brain barrier. It induces oxidative stress and lipid peroxidation, resulting in neurodegeneration. Resveratrol (RSV) has been established to possess several beneficial properties, including antioxidant and anti-inflammatory effects. The present study aims to assess the neuroprotective effects of resveratrol and its synthesized analogue in Sodium Fluoride (NaF)-induced neurodegeneration in Wistar rats. The rats were given NaF, resveratrol, and its analogue for 14 days, and behavioural tests were conducted. Rats treated with resveratrol and its analogue exhibited increased motor coordination and decreased response time to external stimuli. Oxidative stress markers, lipid hydro-peroxide (LPO) and superoxide dismutase (SOD), were normalized in the treated groups. The antioxidant activity was found to increase dose-dependently. Histological analysis showed that resveratrol and its analogue reduced structural deformities in the brain tissue of rats treated with Sodium Fluoride. The degree of neuroprotection was significant in the groups treated with resveratrol and its analogue. Therefore, the synthesized analogue of resveratrol is a potent neuroprotective compound that could be an alternative to resveratrol due to its availability and ease of synthesis. This study highlights the importance of developing new therapeutic strategies for neurodegenerative diseases induced by fluoride intoxication.