Nevirapine (NE) is a BCS class II drug used in the prevention of HIV/AIDS, specifically HIV-1. Its inadequate physicochemical characteristics, such as its low affinity for water and slow dissolution rate, continue to be a barrier to creating new formulations. In this study, cocrystal formation is a contingent feature that involves ionic or non-covalent intermolecular interactions between an active moiety and a coformer in a crystal lattice for creating NE cocrystals with favourable physicochemical characteristics. The coformers chosen were Nicotinamide (NA) and Succinimide (SI) which demonstrated encouraging results in terms of enhanced water solubility and dissolution rate. NE cocrystals were synthesised in 1:1 stoichiometric ratio utilising liquid-assisted grinding method with liquid acetone, which acted as a catalyst to accelerate reaction kinetics. Analytical methods such Fourier transform (FTIR), Powder X-ray diffraction (XRD), SEM, and differential scanning calorimeter were used to analyse the novel cocrystals of NE. All of the studies revealed the formation of cocrystals with increased solubility and dissolution rates. The thermal stability The dissolution studies revealed that NE-NA (1.94-fold) and NE-SI (1.86-fold) were more soluble than pure NE. The NE-NA and NE-SI cocrystals in phosphate buffer at pH 6.8 exhibit higher dissolution rates than pure NE. The positive attributes of cocrystallization in strengthening the drug's physicochemical features were shown by changes in the chemical environment, an enhancement in solubility, and an increase in dissolution rate.