Background: Mechanical and inflammatory alterations are linked to the progression of hemodynamic instability in normotensive patients with Acute Pulmonary Embolism (APE). Objective: This study aimed to evaluate the ability of some new inflammatory parameters to predict the outcome of normotensive APE patients in an In-hospital setting. Patients and Methods: This prospective cohort study included 62 normotensive patients diagnosed as acute pulmonary embolism by CTPA. Neutrophil-Lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) were estimated during hospital stay. According to outcome they were divided in two groups. The indices were compared in both groups. Conclusions: NLR and PLR are useful tools independently or combined to identify normotensive patients with APE to predict short-term poor outcome.