This study discusses Post Herpetic Neuralgia (NPH), a common complication after shingles. NPH is characterized by pain that persists for 3 months after healing of the herpes zoster lesions. Studies show an association between increasing age and the incidence of NPH, with approximately 9-34% of herpes zoster patients experiencing NPH. The incidence is higher in the age group over 60 years. NPH causes chronic neuropathic pain and affects the patient's quality of life. The treatment of NPH is unclear, but multimodality therapy and botulinum toxin (BTX) may have good results. BTX works by reducing the release of pain and inflammatory mediators. Several studies have shown pain relief after using BTX in NPH patients. This study reported a series of post-herpetic neuralgia cases in a man, aged 59 years, a woman, aged 54 years, and a woman, aged 50 years. From anamnesis, complaints of pain in the back after the lesion onset were reported. Patients have similar complaints of pain, such as burning, pricking, and discomfort. Complaints of this pain vary between 1 and 3 months after the herpes zoster skin lesions have healed. This causes the patient to have difficulty sleeping at night and interferes with the patient's daily activities.