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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
Novel triazole derivatives' design, synthesis, characterisation, molecular docking, and in vitro antimicrobial activity of N-(4-(3-oxomorpholino) phenyl)-2-(4-((phenylamino)methyl)-1h-1,2,3-triazol-1-yl) acetamide
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Abstract
The novel collection of triazole derivatives has been synthesized, characterized through spectroscopic methods (Infra-Red, Proton NMR, and Mass Spectroscopy). The biological activity and MIC (Minimal Inhibitory Concentration) of this as synthesized compound N-(4-(3-oxomorpholino)phenyl)-2-(4-((phenylamino)methyl)-1H-1,2,3-triazol-1-yl)acetamide (HP1-HP10) have been screened against gram-negative pathogens (2) and fungi (3). HP03 and HP07 have potential action against gram-negative bacteria as well as fungus strains. And molecular docking studies site specific of all the ten tetrazole moieties done through PyRx shown the compound HP03 and HP07 have good binding affinity against PDB: 1KZN,1UKC,1IYL,4JVI,5C5G
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