Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain, fever, and inflammation. Despite their efficacy, their use is associated with a range of adverse events due to their mechanism of action. This article discusses the mechanisms of NSAIDinduced adverse events, the factors that contribute to their occurrence, and the implications for patient safety. NSAIDs are a commonly used class of medications for the treatment of pain, fever, and inflammation. They work by inhibiting the production of prostaglandins, which are involved in the regulation of these symptoms. While this mechanism is effective for symptom relief, it can also lead to a range of adverse events due to the various physiological functions of prostaglandins. In this article, we will discuss the mechanisms of NSAID-induced adverse events, the factors that contribute to their occurrence, and the implications for patient safety. NSAIDs are an effective and widely used class of medications for the treatment of pain, fever, and inflammation. However, their use is associated with a range of adverse events due to their mechanism of action. Careful patient selection, monitoring, and education are important to minimize the risk of adverse events and ensure the safe and effective use of these medications.