Background: Pharmaceutical care plays a critical role in optimizing patient outcomes by focusing on medication use and health improvement. Interprofessional collaboration among healthcare stakeholders is essential for effective pharmaceutical care delivery. Nurses and pharmacists are key players in this process, contributing to patient care through various roles and responsibilities. However, there are reported deficiencies in nurses' competencies in pharmaceutical care, underscoring the need for enhanced education and training in this domain. Objective: This review aims to assess the current level of collaboration between nurses and pharmacists in providing pharmaceutical care, evaluate the impact of interprofessional, evidence-based collaboration on patient care and outcomes, and provide recommendations for enhancing collaboration between these professionals to improve patient care quality and outcomes. Conclusion: Optimizing pharmaceutical care through interprofessional collaboration between nurses and pharmacists is vital for enhancing patient outcomes and ensuring safe medication use. While nurses play a significant role in pharmaceutical care, there are identified gaps in their competencies, emphasizing the importance of improved education and training. Pharmacists also play a crucial role in enhancing pharmaceutical care by ensuring medication safety and efficacy. To strengthen integrated, evidence-based pharmaceutical care, clear communication among healthcare professionals, ongoing research on interprofessional collaboration, and the development of collaborative frameworks are essential. By addressing barriers and focusing on facilitators of high-quality interprofessional pharmaceutical care, healthcare providers can work together to enhance care quality, patient outcomes, and the overall healthcare experience.