Clinical alarms are the most essential component of most of the medical devices in intensive care units that gain attention of critical care nurses for immediate or potential threats facing critically ill patients .If nurses not have enough knowledge and skills to management clinical alarms that can lead to deterioration of patient condition or even death, so assessment of nurses’ performance when managing clinical alarms is very critical. Aim :This study aimed to assess nurses’ performance regarding devices’ alarms in ICU. Design: A descriptive exploratory research design was used. Setting: The study was conducted in ICU at ELFayoum General Hospital. Subjects: A Convenient sample of all available nurses (50) nurse from both sex working in the intensive care. Tools: three tools were used for data collection. Tool I: Nurses’ self administered interview Questionnaire: which included (a) Demographic characteristics of nurses (b) Nurses’ knowledge regarding devices alarms in ICU, Tool II: Observational check list for nurses` practice which included (a) Observational checklist for assessment of nurses ‘practice in devices alarms management for three devices (monitorـventilatorـsyringe pump)(b) False Alarm Prevention Checklist Tool III: Nurses` attitude rating scale assessment questionnaire. Results: the study results reported that 76% of the studied nurses had unsatisfactory level of total knowledge and 64% had incompetent level of total practices 58% had positive attitude regarding devices alarms in ICU. Conclusion: There was highly statistically significant, correlation between total knowledge, practice and attitude regarding devices alarm in ICU. Recommendations: Continuing educational program to improve knowledge and practices of nurses regarding devices alarms in ICU.