Background: Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease with poor patient outcomes, the hyperammonemia is a key factor in the pathogenesis of it. HE reduces the patient's quality of life and increase caregiver's overload. Nurses have a critical role in prevention of complications and it is important to study their level of knowledge, practice, and attitudes. Study Aim: Assess nurses' performance regarding management of patient with Hepatic encephalopathy at endemic care unites. Design: A descriptive study was utilized to meet the aim of this study.