During their stay in the hospital, a significant number of patients require the administration of one or more blood components. Consequently, it is essential for nurses to have a thorough understanding of who is accountable for the rapid administration of blood transfusions, the monitoring of patients, and the identification and management of transfusion reactions. A much higher degree of knowledge was possessed by nurses who had both a higher level of education and a longer period of working experience. It is possible that the findings might serve as the foundation for the development of structured continuous education, which would lead to a gain in knowledge, an improvement in practice, and a reduction in the risks to patient safety during the transfusion procedure.