Cardiac Catheterization (CC) is a diagnostic and interventional tool that is considered the gold standard for evaluating heart problems today. Nurses in the Cardiac Catheterization Lab (CCL) play an important role in providing patients with high-quality care. Aim: The study was aimed to evaluate nurses' role and patients' outcomes regarding care of cardiac catheterization. Research design: A descriptive design was used. Tool of data collection: A Structured Interview questionnaire for nurses, An Observational checklist and A Structured Interview Questionnaire for patients Setting: El Zagazig university hospital, cardiothorathic hospital and Elahrar hospital, Egypt. Study subjects: A purposive sample of patients in above settings, (50) and all available nurses working in the mentioned setting (50) nurse. Result: current study revealed that more than two third (68.0%) of studied nurse had unsatisfactory total knowledge regarding care of Cardiac Catheterization. More than half (56%) of studied nurse had satisfactory practice level regarding care of cardiac catheterization, according to nurses' practice regarding patient safety the majority (88.0%) of studied nurses had adequate level of practice, concerning patients 'outcome more than three quarter (76%) of the studied patients free from complications and more than half (56%) of the studied patients were dissatisfied regarding care post cardiac catheterization. Conclusion: the study finding concluded that there was a highly statistically significant positive correlation between total nurses’ knowledge and nurses’ practice regarding care of patient undergoing cardiac catheterization at (p = 0.000). Also, there was a highly statistically significant positive correlation between total patients’ satisfaction and nurses’ knowledge and practice during cardiac catheterization at (p value was 0.005 and .007 respectively). Recommendations: develop an educational program for nurses in CC unit to provide the adequate performance needed to deal with such group of patients.