This review article synthesizes current literature on nursing interventions and their impact on reducing sepsis mortality. Sepsis remains a global health challenge, necessitating a comprehensive understanding of nursing strategies to enhance patient outcomes. The review encompasses studies from diverse sources, including PubMed, Web of Science, and Cochrane, focusing on interventions implemented by nurses in sepsis management. Key interventions explored include early recognition, timely administration of antibiotics, fluid resuscitation, vasopressor therapy, and continuous monitoring. The critical role of nurses in initiating these interventions is emphasized, illustrating their pivotal position in the frontline of sepsis care. The article delves into the nuanced aspects of nursing contributions, such as patient and family education, emotional support, and post-acute care. By thoroughly analyzing the literature, this review aims to provide evidence-based insights into the effectiveness of nursing interventions, elucidating their direct impact on reducing sepsis-related mortality. The synthesis of findings seeks to inform healthcare practices, foster continuous improvement in nursing care protocols, and guide future research directions to further enhance sepsis management strategies. Ultimately, the comprehensive understanding offered in this review underscores the indispensable role of nurses in mitigating sepsis mortality and promoting holistic patient care.