Pain management in the emergency room is a critical aspect of patient care, with nurses playing a vital role in assessing, monitoring, and alleviating pain. This review article examines various nursing interventions employed in the emergency room setting to effectively manage pain in patients. The article explores the use of pharmacological and non-pharmacological interventions, highlighting their efficacy, safety, and patient outcomes. Additionally, the role of nurses in advocating for adequate pain relief, educating patients on pain management strategies, and collaborating with multidisciplinary teams is discussed. The review also addresses challenges faced by nurses in pain management, such as time constraints, communication barriers, and balancing pain relief with other clinical priorities. By synthesizing current evidence and best practices, this article aims to provide insights into optimizing nursing interventions for pain management in the emergency room, ultimately improving patient satisfaction and outcomes.