Hospital-acquired infections (HAIs) pose a significant threat to patients in intensive care units (ICUs), leading to increased morbidity, mortality, and healthcare costs. Nurses play a crucial role in implementing interventions to prevent and reduce HAIs in ICUs. This review article aims to explore the various nursing interventions that have been employed to combat HAIs in ICUs. The interventions discussed in this review include proper hand hygiene practices, environmental cleaning, implementation of infection control protocols, surveillance and monitoring of infections, use of personal protective equipment, and education of healthcare staff and patients. The effectiveness of these interventions in reducing the incidence of HAIs and improving patient outcomes will be critically evaluated. Furthermore, challenges and barriers faced by nurses in implementing these interventions will be discussed, along with potential solutions to overcome them. By synthesizing current evidence and best practices, this review article provides valuable insights into the role of nursing interventions in the prevention and management of HAIs in ICUs, ultimately aiming to enhance patient safety and quality of care in critical care settings.