This study aimed to evaluate the readiness of nursing, radiology, and epidemiology workers for emergencies and public health challenges in hospitals and health centers in the city of Riyadh. The study sample consisted of (200) individuals working in nursing, radiology, and epidemiology in hospitals and health centers in the city of Riyadh. The study sample consisted of (200) individuals working in nursing, radiology, and epidemiology in Saudi hospitals. Quantitative research was used through a questionnaire that included: 10 dimensions of emergencies and public health challenges. The results of the study showed that the study sample had good knowledge in all theoretical dimensions of emergency management and public health challenges. The study sample also indicated that there were noticeable weaknesses in some practical dimensions of emergency management and public health challenges in terms of assessing the extent of their own preparedness, which indicates the need to enhance their contribution. Practical as well as their theoretical knowledge of emergencies and public health challenges.