Although early childhood tobacco smoke exposure has been extensively examined, the impact of second-hand smoke (SHS) in new-onset respiratory symptoms and lung function decrease in adults has received less attention in longitudinal investigations. We search the electronic databases; PubMed and Embase for all the studies that were published discussing the concern topic. According to newly revealed information, even quick and short-term SHS exposure has considerable negative consequences on the human respiratory system. SHS has been found to be independently related with respiratory tract symptoms such as sneeze, sore throat, cough, and nasal rhinitis. Chronic SHS exposure of those who worked in hospitality settings contributed to decreased exercise performance among healthy adult nonsmokers. Its impact on the development of chronic diseases should be investigated further.