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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
Oncolytic activity of herpes simplex virus type II (oHSV-2) on Colorectal cancer (CRC)
Main Article Content
Abstract
The rising prevalence of cancer worldwide has led to the emergence of several biotechnological advancements, including oncolytic virotherapy, a novel treatment strategy for multiple tumors. Among these approaches, herpes simplex virus (HSV) based vectors have garnered significant attention as extensively researched oncolytic agents on a global scale. In this study, We investigated in vitro the effects of oHSV2 with singular gene deletion gama 34.5 Expression recombinant HSV-2 virus or infected cell protein 47 Expression recombinant virus (ɣ34.5 ExRV or ICP47 ExRV) and viruses with deletion of both genes ɣ34.5 & ICP47 Expression recombinant virus (Dual ɣ34.5 & ICP47 ExRV), on the LS174T colorectal adenocarcinoma cell line model compare with a normal vero cell line
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