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ISSN 2063-5346
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ONE POT BF3.MeCN CATALYZED SOLVENT FREE SYNTHESIS OF 3,4-DIHYDROPYRIMIDINE-2-ONE ANALOGUES

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Ajit A. Kharpe[a], Tukaram S. Choudhare[a], Santosh N. Mokale[b] and Prashant D. Netankar[a]*

Abstract

One-pot solvent free three components coupling of aryl aldehydes, β-dicarbonyl compounds, urea or thiourea was performed to afford corresponding 3,4-dihydropyrimidine-2-ones and their sulfur analogs 3,4-dihydro-pyrimidine-2-thiones. It is the first report of BF3.ACN catalyzed the solvent-free synthesis of pyrimidone analogs.

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