In order to synthesize polycyclic scaffolds, the fundamental stages use one-pot techniques called inter- or intramolecular alkyne annulation. These scaffolds are either present in natural products or are associated to them. These methods are either immediately associated with natural products or can be discovered in natural products themselves. We are going to talk about the processes that may be utilized to make particular polycyclic carbocycles and heterocycles that include three or more fused, bridged, or spiro rings. In-depth research will be conducted on the topics of efficient synthetic process and prospective product variety. In this article, we will talk about the many synthetic techniques that may be utilized to synthesis chosen Carbohydrates and heterocycles having at least three ring structures that are fused, bridged, or spiro are considered to be heterocycles. This type of structure is referred to as "at least three fused, bridged, or spiro rings," and substances that have it are called "at least three fused rings." The efficiency as well as the variety of the many different synthetic technologies that are currently accessible will be emphasized. This article focuses on recent applications of recently developed synthetic ideas or toolkits as its primary topic of discussion. C-H functionalization, dearomatization, gold catalysis, collective and divergent total synthesis are all examples of these types of reactions. One-pot cyclization’s can be accomplished by the utilization of either multicomponent processes or multifunctional substrates. These reactions are very helpful for the modular and combinatorial synthesis of PNPs as well as the generation of compounds that possess features that are comparable to those of natural products.