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ISSN 2063-5346
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ONE-POT SYNTHESIS OF 3-AMINO-CHROMEN-2- ONES AND THEIR ANTIMICROBIAL STUDY

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Tirth Thaker, Sweta Maurya, Om Trivedi, Bhumika Soni, Riya Parmar
» doi: 10.31838/ecb/2023.12.s3.616

Abstract

Bromination of 7-Hydroxy-4-methyl-2H-chromen-2-one (3) gives 3-Bromo-7-hydroxy-4- methyl-2H-chromen-2-one (4) which on condensation with different amines, gives 3-Amino analogs of 7-hydroxy-4-methyl-chromen-2-ones (6a-d). These title compounds are confirmed by spectral Analysis as FTIR and NMR. These compounds were subjected to microbial activity against Escherichia coli (gm-ve), Staphylococcus aureus (gm+ve) bacteria, and antifungal activity against Candida sp fungi and showed good results.

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