Background: Prosthetic aortic valve replacement is the standard and traditional procedure for aortic valve lesions; however thromboembolic and hemorrhagic events could be associated with the use of prosthetic valves. The purpose of our study is to address the early postoperative results and benefits after aortic valve reconsrtuction using Ozaki technique. Methods: 40 patients with aortic valve diseases underwent aortic valve surgery through valve neocuspidization at cardiothoracic surgery department at Cairo university hospitals in the period between March 2020 and November 2020. Results: The mean age was 52.23 ± 22.64 years. 32 (80%) patients had severe aortic stenosis while 8 (20%) patients had severe aortic regurge. Postoperatively there was statistically significant decrease in the peak and mean pressure gradients across the valve (P-value 0.0001) and increase in effective orifice area (P-value 0.0001). 29 (72.5%) patients had no aortic regurge while the other 11 (27.5%) patients had mild aortic regurge. There was freedom of need to convert to prosthetic valve replacement. There was one in-hospital mortality due to severe impairment of RV systolic function. Conclusion: Aortic valve neocuspidization with the use of gluteraldehyde treated autologous pericardium might be a feasible procedure that is associated with good immediate results regarding the valve hemodynamics together with lack of need for lifelong anticoagulation.