Emulsomes formulation becomes the emerging delivery system for the active constituents isolated from the plant extract. Emulsome provide the enhanced entrapment efficiency as well as sustainability of the drug at the site of action. In the present study the emulsomes formulation optimised via Box Behnken design expert software. Stigmasterol isolated compound from the flowers extract of Cristata Sciata loaded in the optimised emulsomes formulation. Additionally it was compared with the standard Active constituents. This formulation was further analysed and characterised via entrapment efficiency, morphological study (SEM) , drug release and so on. As result it was concluded that isolated compound was equivalent active as the standard compound