Zaltoprofen, which is a non-selective COX inhibitor, is very beneficial in arthritis especially rheumatoid arthritis. It has a very short half-life of 4.96± 2.96 hr. The drug has different side effects like ulceration, nausea, vomiting, constipation, loss of appetite, and urinary disturbance when taken orally. The Transdermal Emulsified gel of Zaltoprofen was formulated by using varying concentrations of Light Liquid Paraffin and Carbopol934p. The Emulgel was characterized for physical appearance (Colour, Phase separation, Homogeneity, Consistency), pH, Spreadability, Viscosity, Extrudability, Drug content, In-vitro drug release study, Stability study. A 32 factorial design was used to determine the effect of the Carbopol 934P and Light Liquid Paraffin on various parameters such as Spreadability, Viscosity, % CDR at 12 hr. The responses were analyzed using ANOVA & by the predictive equation by design expert. From study It was established that Light Liquid Paraffin and Carbopol934p significantly affect all the parameters. The developed formulation F7 shown very satisfactorily results of Spreadablity25 ± 0.53mg*cm/sec, Viscosity 3817 ± 0.62 cps and percentage cumulative drug release at 12thhour was 96.62±0.76%. The most appropriate formulation was found to be stable for one month during stability study.