These days the use of optimization software has become the most appropriate and realistically useful experimental designs and optimization approaches so to identify the different potential approach accessible to improve the quality, safety, and effectiveness of pharmaceutical products. To reach the optimal composition of formulation and process attributes under the predetermined set of conditions, we will discuss the most contemporary software, experimental designs, and optimization techniques. Different computer software plays a crucial function in keeping track of and maintaining the current pharmaceutical business processes. The methods that are simultaneously and systematically utilized to detect various types of issues that may affect pharmaceutical formulation research, development, and production include experimental designs and optimization procedures. Establishing the relationship between the influences on a process and its outcomes can be done systematically. To improve product quality by utilising the most appropriate facilities, various softwares has been employed in the implementation of optimization approaches in pharmaceutical products. The pharmaceutical industry can improve their cGMP practices and regulatory body compliance by installing software like design expert. This review focus on the different softwares available that can be used in many industries, also the major characteristics of the softwares will be discussed.