In this study, the development of a simple, scalable, green and concise alternative process for the manufacturing of Phenyl hydrogen (((R)-1-(6-amino-9H-purin-9-yl)propan-2- yloxy)methyl phosphonate (TPF), which is a promising potent antiviral agent discovered and developed by Cipla Ltd. This study found that carrying a reaction in an aprotic organic solvent or mixture of aprotic organic solvents led to a scalable but economically feasible green process. This process also involved desirable yield, purity and scalability from 10 to 30kg scale of operation.