Orodispersible tablets are the formulation that disintegrates in the mouth within few seconds. These formulations should not be swallowed. Orodispersible tablets are the novel drug delivery system. They are the most common and popularly used among other novel preparations. They are made up of superdisintegrants that make them different from conventional tablets. Use of super disintegrants make the tablets disintegrate within few seconds without using water. They are more useful for older aged people, small children, patients suffering from mental diseases, travelling patients and those who have difficulty in swallowing of tablets. They offer different benefits like improvement in the solubility, dissolution, bioavailability of the drug, better patient adherence to the treatment. ODTs are a boon to the patients and represent a remarkable development in the pharmaceutical industry. Direct compression is the most commonly used technique for the formulation of ODTs. Other methods include wet granulation, sublimation process, spray drying technique and many others. Different patented technologies are also used for the formulation of Orodispersible tablets. These days orodispersible tablets are easily available for treatment of different diseases. This review article includes advantages, limitations, ideal characteristics of superdisintegrants, different techniques for preparing ODTs, patented technologies, challenges in the formulation, mechanism of superdisintegrants and different evaluation parameters.