Objective: To find the correlation between risk factors and Carpal Tunnel Syndrome (CTS) symptoms in dentists in Maluku and North Maluku Material and Methods: A cross-sectional survey was conducted on 182 dentists registered in Indonesian Dentist Association (Persatuan Dokter Gigi Indonesia/PDGI) in the province of Maluku and North Maluku, Indonesia. A self-administered questionnaire were distributed online. It consisted of two parts, individual characteristics in the first part and the Boston CTS questionnaire in the last. The data were analyzed by Pearson’s Correlation test using SPSS version 26 and presented in frequencies and percentages. Results: A total of 182 dentists participated in this research out of whom 52 (28.6%) were males and 130 (71.4%) were females. Total 87 (47.8%) dentists reported the symptoms of CTS with 18 (9.89%) had functional impairment in hand and wrist. CTS symptoms appeared to increase in age, where 85.7% of dentists over 50 years had these symptoms (p=0.000). Dentists with high Body Mass Index (BMI) were more likely to complain of CTS symptoms than dentists within normal BMI (p=0.000). Occupation period was also correlated with CTS symptoms (p=0.000). However, there was no relationship between CTS symptoms and gender or duration of working with vibrating tools. Conclusion: Dentists in Maluku and North Maluku appeared to have CTS symptoms. Age, high BMI and more years of working experience were related with CTS symptoms. No correlations were found between gender or duration of working with vibrating tools and CTS symptoms.