Hysteroscopy is a minimally invasive intervention that can be used to diagnose and treat many intrauterine and endocervical problems. Hysteroscopic polypectomy and myomectomy are just a few of the commonly performed procedures. Given their safety and efficacy, diagnostic and operative hysteroscopy have become standards in gynecologic practice.Operative hysteroscopy is best performed after menstrual flow has stopped in the proliferative phase of the menstrual cycle because it is when the endometrium is thin. We can also achieve that by inducing endometrial atrophy by using different drugs such as progestins, combined oral contraceptive pills, gonadotropin-releasing hormone agonist, or danazol. There is no rule for using prophylactic antibiotics routinely for most hysteroscopic procedures because postoperative infection rates are low.Misoprostol, a prostaglandin E1 analog, which was initially used for the treatment of peptic ulcers, has been widely applied in obstetrics and gynecology because of its ripening effect on cervix during the induction of abortion or labor. Hyoscine-n-butyl bromide (HBB) is a peripheral anticholinergic and does not readily cross the blood-brain barrier.The effects of misoprostol or Hyoscine Butylbromide use on cervical priming prior to hysteroscopy have been controversial. The aim of the present study was to review the using of misoprostol or hyoscine butylbromide as a cervical priming agent prior to hysteroscopy.