Psoriasis is a common, genetically determined, inflammatory and proliferative dermatological disorder that affects skin, nails & joints characterized by keratinocyte hyperplasia leading to erythematous oval plaques with adherent silvery scales and has various systemic involvements. Psoriasis has been associated with an increased risk of atherosclerosis, including coronary artery disease (CAD) and stroke, for decades. Recent evidence suggests that oxidation (Ox) of LDL plays an important role in the pathogenesis of atherosclerosis and cardiovascular diseases. Our study therefore aims to assess ox-LDL and lipid profile in patients with psoriasis with an objective to observe and report any significant deviations in the same as compared to healthy controls. Materials & Methods: Fifty (50) clinically diagnosed cases of psoriasis and fifty age and gender-matched healthy controls from the general population were enrolled in the study. Estimation of lipid profile was assayed by standard photometric methods in auto analyzer ERBA-XL (EM-200) using commercially available kits and VLDL cholesterol was calculated using the formula adopted by Friedewald’s and colleagues.12 Estimation of Human Ox-LDL (Oxidized Low Density Lipoprotein) was done by using ELISA Kit (Elabscience, USA).