Background: Effective pain management in emergency departments is crucial for ensuring patient comfort and satisfaction. However, assessing and treating pain in this setting can be complex due to the multidimensional nature of pain and the need for standardized measurement tools. Various pharmacological and non-pharmacological interventions are available for acute pain relief, but their efficacy and impact on patient outcomes need to be evaluated. Objective: This review aims to assess current pain management practices in emergency departments, identify effective interventions for acute pain relief, evaluate their impact on patient outcomes and satisfaction levels, and provide recommendations for improving pain management strategies based on research findings. Conclusion: The review highlights the importance of standardized pain assessment tools in emergency care settings and the use of appropriate pharmacological interventions such as morphine, fentanyl, ketorolac, ibuprofen, and paracetamol. Regional blocks like femoral, hematoma, Beir, axillary, and occipital blocks are also discussed as effective pain management strategies. Inadequately managed acute pain can lead to various consequences, emphasizing the need for safe, timely, and effective trauma pain management protocols in emergency settings. Addressing barriers to pain management, such as delayed assessments and hesitancy in opioid use, is crucial for improving patient care in emergency departments.