Background and Aim: This is an era of continuous research that warrants the instigation of new ideas and their effective implications. For decades, it is a common practice to preserve the paraffin-embedded tissue blocks after histopathological reporting. Somehow, very less evidence is available in the literature confirming the utility of the same. We hypothesize that sectioning of preserved blocks after a due period may show noticeable morphological changes. The present study was planned to compare subjective and morphometric changes in old and freshly prepared slides from the same paraffin-embedded tissue blocks. Materials & Methods: 2 groups were formed, Group 1(old) and Group 2 (new). Group 1 consisted of old slides and Group 2 consisted of freshly prepared slides made from the same paraffin blocks. 100 archival Hematoxylin & Eosin-stained slides were randomly chosen from the year 2008 to 2011. 47 slides were selected and blocks of the same were identified and resectioned and fresh slides were prepared. These were subjected to standard subjective and objective analysis. Student paired “t” test was used. Results: The observation and results of the subjective and morphometric (objective) analysis proved that there were no significant changes when the 2 groups were compared. Conclusions: We concluded that there was hardly any change in the architecture of tissues of preserved blocks after 15 to 16 years.