Background: Sepsis and septic shock are common conditions that are associated with unacceptably high mortality and for many of those who survive, long-term morbidity. The world health assembly and WHO made sepsis and septic shock a global priority and adopted a resolution to improve the prevention, diagnosis, and management of sepsis and septic shock. Increased awareness of the septic condition resulting from ongoing campaigns and the evidence arising from research in the past 10 years have increased understanding of this problem among clinicians and have led to improved outcomes. Early identification and appropriate management in the initial hours after the development of sepsis improve outcomes. In septic shock there is an intense inflammatory response leads to marked vasodilation and hypotension. Monitoring of the peripheral circulation can be done noninvasively in contrast to the more traditional invasive systemic haemodynamic monitoring in the intensive care unit. Physical examination of peripheral circulation based on clinical assessment has been well emphasized for its convenience, accessibility, and relation to the prognosis of patients with circulatory shock. Early resuscitation is a key factor to limit progression to multiple organ dysfunction and death in patients with septic shock and this highlights the need to identify the best parameter to be targeted during therapy of shock aiming to achieve maximum benefit to those critical patients.