This research paper aims to study the initiatives to be taken by Universities through the development and promotion of Innovation and entrepreneurship. Traditional Universities role has gradually evolved and changed and they are now redirecting the new knowledge, student’s innovations for nations economic development through University Incubation centres. A parametric model is developed to illustrates how University Innopreneurship is functioning for the selected parameters. Current research paper is dealing with understanding and analysing the changing dynamics of University education system in nurturing University Incubation through various parameters affecting the same by Taguchi method. The Taguchi analysis result shows that the university Leadership and Governance is the major factor influencing the innopreneuship process. This also provides a sound platform for young entrepreneurs for their innovative ideas through innopreneurship process.