Hemodialysis refers to how well toxins and waste products are removed from the patient’s blood and has a major impact on their well-being. Hemodialysis delivery should be adequate to improve adequacy of life and to prolong survival. Aim to assess the patients’ perception regarding hemodialysis in Zagazig university hospital based on the knowledge, practice and attitude model. Subject: Design: A descriptive research design was used in this study. Sample: Convenient sample equal 217 of patients who have renal failure and undergoing hemodialysis. Setting: This study was conducted at hemodialysis units in Zagazig university hospital at Zagazig city, Sharkia governorate, Egypt. : -Tools: One tool was used, interviewing questionnaire sheet composed of 5 parts;(demographic data of patient, medical history, patient knowledge about hemodialysis , the reported practice and attitude of patient about the hemodialysis) Results: 69.1% of the studied patients had unsatisfactory level of total knowledge regarding hemodialysis, while 30.9% of them had satisfactory level, 57.1%of the studied patients had inadequate level of total reported practice regarding hemodialysis and 42.9% of them had adequate level, 71.6%of the studied patients had negative attitude regarding hemodialysis. While, 28.4% of them had positive attitude. Conclusion there was a low level of knowledge and attitude that is correlated with subjects' practice scores. Also observed a positive correlation between attitude and practice scores. Recommendations: Developing health educational programs that would help patient to increase knowledge, improve practice and attitude regarding hemodialysis