Osteoarthritis secondary to osteonecrosis of the femoral head is a common presentation in patients with sickle cell disease. Functional limitations with or without deformities from these complications of sickle cell disease often require Total Hip Replacement to improve outcome. However, arthroplasty surgeons have been hesitant to perform replacements on individuals who are 30 years old due to concerns regarding potential medical complications, survivorship and the challenging inevitable revisions. We have conducted this study to understand the patients’ satisfaction considering above complications and to assess the pain intensity of hip joint and health related quality of life as well as evaluate the duration of return to occupation/ activity of daily living post Total Hip Replacement. Material & Method: Study was conducted in form of questionnaire for the patients operated with total hip replacement with sickle cell disease. Apart from personal details, Harris Hip score and Visual Analogue Scale were used in questionnaire to assess quality of life, return to occupation and pain level of patient respectively. Data was collected in pre tested, pre formed questionnaire along with basic personal details. The outcome measures were taken pre operatively and 6 weeks after surgery (post operatively) for comparison. After which the result of the study was evaluated using the data collected according to the Performa at stipulated duration. Results: Out of 20 SCD patients, 9 developed avascular necrosis in 20-25 age group and 9 developed AVN in 26-30 age group.. Mean duration of illness in present study was found to be 19.2 months in which 45% patients were suffering for a duration of 1-2 years. Overall improvement was seen in the limp, and most of them having compliance and improvement in their gait. Walking ability was significantly improved in terms of support from 80% to 15% post operatively eliminating need for support among most of them. VAS score improved from a mean of 7.15 in pre-operative evaluation to 1.85 in post-operative evaluation and the Harris Hip score was improved from mean of 45.6 to 86.15 in post-operative evaluation. Majority of patients returned to their occupation within 6 weeks after surgery. Conclusion: The study concludes that THR is an effective surgery in reducing pain intensity and improving quality of life in patients with avascular necrosis of hip due to sickle cell disease. The study also shows that limp was reduced post THR as well as patients required less walking support after surgery.