Public perceptions regarding the prevention of CKD play an important role in the recovery of patients in survive. This study examines the cultural aspects experienced by patients in understanding their illness. This study used a qualitative research method with in-depth interview techniques to patients at Mayjend HA Thalib Kerinci Hospital. The focus of this research is to look at the perceptions of the Kerinci people in preventing CKD. The findings show that there are patient perceptions of CKD disease, patient family perceptions of CKD disease, treatment of CKD disease, belief in traditional medicine, obstacles to implementing discharge planning, health worker services, patient compliance and the process of implementing discharge planning. The results of the study showed that there were misperceptions and the patient's trust in the local culture was still high. Shows the low knowledge and confidence of chronic kidney failure patients at Mayjend HA Thalib Kerinci Hospital, which affects treatment adherence which results in the severity of kidney conditions. Meanwhile, the cultural-based regional language factor in communicating with patients is highly recommended so that messages can be well received by patients.