Rising price, increasing demand and limited resources of petroleum products requires an alternative fuel produced from eco-friendly resources. Biodiesel produced from various organic resources like vegetable oils, non-edible oils, animal fats are increasing interest for the researchers as an alternative to the diesel. The present work consists of performance analysis of single cylinder diesel engine employing turmeric leaf oil (curcuma longa) based biodiesel with three different biodiesel blends viz. B10, B20 and B30 and its comparison with the commercial diesel. For comparative analysis, the engine was operated at varying engine loads, compression ratio and fuel injection pressures using diesel as well as biodiesel blends. The engine records highest brake thermal efficiency of 24.84% and lowest BSFC of 0.28 kg/kWh at 600 bar injection pressure, compression ratio of 18 and at full engine load with diesel fuel. At same operating conditions, the BTE and BSFC recorded are 23.84% and 0.29 kg/kWh for B10, 23.38% and 0.32 kg/kWh for B20 and 23.22% and 0.34 kg/kWh respectively. All biodiesel blends exhibit comparable performance to the diesel in terms of BTE and BSFC at all engine operating conditions. The B10 blend shows better performance amongst all biodiesel blends