Background: Periodontal diseases are prevalent globally, affecting a significant portion of the population. Factors such as inadequate oral hygiene, smoking, diabetes mellitus, and genetic predispositions play crucial roles in their development. These diseases are associated with systemic conditions like cardiovascular disease, diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease, emphasizing the importance of maintaining good oral health. Objective: This review aims to examine the relationship between periodontal disease and systemic conditions, explore potential mechanisms linking them, evaluate preventive measures' effectiveness, assess the impact of periodontal disease on health and quality of life, and provide evidence-based recommendations for healthcare providers and patients. Conclusion: Periodontal diseases are highly prevalent and linked to various systemic conditions. Inadequate oral hygiene, smoking, diabetes, and genetic factors contribute to their development. The bidirectional relationships underscore the significance of good oral health practices. Preventive measures such as regular dental cleanings, proper oral hygiene, and lifestyle modifications are essential for managing both periodontal diseases and associated systemic conditions. Healthcare providers and patients should collaborate to effectively prevent and manage these conditions, recognizing their impact on overall health and quality of life.