Maintaining the quality of medication and pharmaceuticals has always been an area of major concern in today’s world. The process is very complex and therefore needs to consider different types of rules and guidelines such as GMP and GLP. Quality management has emerged to be an important subject of matter in pharmaceutical industries [1]. Hence many laboratories and pharmaceutical industries are now giving more importance on proper implementation of an effective Quality Management System. Pharmaceutical Quality Management System (QMS) generally refers to procedures and practices which help in contributing to the overall quality of product. It ensures effective and efficient execution of tasks within organization [1]. Implementation of a proper Quality Management System is very important as it can help a pharmaceutical organization in fulfilling its responsibilities like quality, safety, efficacy of pharmaceutical product. A well developed QMS can easily assimilate the procedures and it can help in effective improvement of quality in all pharmacy related areas as well as satisfaction of customer, reduction of errors, variability and therefore improving the healthcare outcomes. Various software systems are available in the market for effective implementation of QMS. It comes with various features like auditing, documentation, corrective and preventive action (CAPA), training management, investigation management etc. This review paper focuses on different types of QMS Software and its importance in Pharmaceutical industries.