Background: Medication errors are a pervasive issue in healthcare systems worldwide, posing a serious threat to patient safety. These errors can lead to prolonged hospitalization, increased treatment costs, and even death. Despite efforts to address this problem, medication errors remain a significant concern, with substantial financial implications for the healthcare sector. Health care professionals involved in the medication process, including physicians, nurses, and pharmacists, are susceptible to experiencing psychological distress due to errors, which can impact patient care and clinical confidence. Objective: This review aims to evaluate the effectiveness of pharmacist interventions in reducing medication errors in hospital settings, assess the types and frequency of medication errors despite these interventions, identify common contributing factors for errors, determine the impact of pharmacist interventions on patient outcomes, and provide recommendations for best practices in pharmacist interventions to enhance patient safety. Conclusion: Medication errors present a considerable risk to patient well-being, emphasizing the critical role of pharmacists in optimizing drug therapy and enhancing patient safety. Various risk factors, including human, system-related, and environmental factors, contribute to medication errors, necessitating the implementation of strategies to mitigate these risks. Different types of medication errors can occur, underscoring the need for improved processes and technologies to enhance medication safety. Pharmacist interventions have demonstrated effectiveness in reducing hospital readmissions and adverse drug events, highlighting the value of their involvement in patient care. Collaborative efforts among healthcare professionals, institutions, and policymakers are essential to foster a culture of accountability, address the root causes of medication errors, and improve patient safety in healthcare settings.