Background: Traditional medicine is the mainstay of care for the majority of Indians who suffer from serious illnesses. The well-known Indian herb Ardisia solanacea (Poir.) Roxb (family: Myrsinaceae) exhibits intriguing pharmacological properties, such as immunomodulatory and cytotoxic actions. Objective: To investigate the pharmacognostic, physical-chemical, GC-MS characterisation, and biological activity of leaves from Ardisia solanacea (AS) plant. Materials and methods: The present study included an organoleptic study, macroscopy, microscopy, powder microscopy, histochemistry, physicochemical parameters, fluorescence analysis, total phenolic content, total flavonoid content, and GC-MS characterization to assess the plant's pharmacognostic potential. Following verification, the plant's leaf extract was successfully tested for in vitro anti-inflammatory and antioxidant properties.