Medicinal plants are worth to nature. The bioactive compounds present in medicinal plants have various pharmaceutical importance. Helicteresisora commonly known as the Indian screw tree (Marorphali), has been reviewed for its phytochemical and pharmacological significance. Traditionally fruits, leaves, barks and roots of this plants has vital therapeutic potential. From traditional time fruits of Helicteresisora has been used for neonates for the dysentery. The plant contain number of active phyto constituents like glycosides, flavonoids, tannins, phenols, alkaloids, saponin etc. The plant has therapeutical importance and mainly shows antidiabetic, antioxidant, anticancer, antinociceptive, antimicrobial, antispasmodic, anti-inflammatory activities. The plant has been used in the traditional system of medicine to treat stomach-related disorders like stomach-ache, diarrhoea, wormicide, snakebite etc. The present study has done to investigate pharmacognostic characters of Helicteresisora macroscopic and microscopic characters, phytochemical screening for glycosides, tannins, saponin, flavonoids, alkaloids etc. Quantitative investigation has done for phenolic content determination by Folin –Ciacaltue Colorimetric method (50 µg/ml shows 51.06 ± 0.99), Flavonoid content determination by Aluminium Chloride Colorimetric method (1000 µg/ml shows 41.10 ± 0.20), and anti-oxidant potential has done by two methods that is DPPH radical scavenging potential (45.56± 0.56) and Nitric Oxide Reducing assay (16.49± 0.32). Thin layer chromatography of extract shows the presence of glycosides, flavonoids, tannins etc.