Biologically active compounds from natural sources are of interest as possible new drugs for different diseases. Over many centuries humans have been mining the bounties of nature for discovering natural products that have been used for the treatment of all human diseases. The genus Miliusa (Annonaceae) has over 60 species that are native to India, Bhutan, Australia, and New Guinea, but are mostly found in numerous Asian nations such as Vietnam, Thailand, and China. Saccopetalum tomentosum (Annonaceae, S. tomentosum) is also known as hoom, kari. It is a huge deciduous tree that may reach a height of 20 metres. Further synonymous name for Saccopetalum tomentosum is Uvaria tomnentosa or Miliusa tomnentosa. S. tomentosum are used as antibacterial, anticancer, anthelmintic, antiparasitic and pesticidal agents. The objective of this study was to investigate pharmacognostical, phytochemical features and in vitro antioxidant activities of leaf of S. tomentosum collected from Bhopal region of Madhya Pradesh. The different pharmacognostical parameters were evaluated as per standard protocols with some modifications. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. Quantitative analysis of phenolic and flavonoids was carried out by Folins Ciocalteau reagent method and aluminium chloride method respectively. The In vitro antioxidant activity of chloroform, ethyl acetate and ethanolic extract of the leaf was assessed against DPPH free radical scavenging assay, SOS activity and reducing power assay method using standard protocols. Phytochemical analysis revealed the presence of carbohydrates, glycosides, alkaloids, flavonoids, triterpenoids and steroids ect. The total phenolics content of leaves ethanolic extract was (323.667mg/100mg), followed by flavonoids (448.333mg/100mg). The activities of all leaves extracts against DPPH, SOS and reducing power assay method were concentration dependent. The diverse array of phytochemicals present in the plant thus suggests its therapeutic potentials which may be explored in drug manufacturing industry as well as in traditional medicine.