The description of millets found in the early phase of human civilization is documented as the oldest cereals. Millets are grown in warm seasons and small-seeded crops. They are a potential source of food and fodder in many parts of the world. They need less requirement of water to grow and have more nutrient profile as compared to major cereals. In the current scenario, many lifestyle disorders affect human being because of their food habit. Millets have a rich source of vitamins, minerals, and phytochemical contents. Phytochemical active ingredients reduce the risk of various disorders like diabetes, hypertension, cardiovascular risk, cancer etc .The main aim of review is to highlight the nutritional profile of millets and attention their pharmacological action