In the current study, we explored the potential of hydroalcoholic and petroleum ether extracts derived from Phyllanthus niruri (L) leaves in addressing antisecretory and antiulcer effects. These extracts were administered orally at varying doses (100, 200, and 400 mg/kg) and evaluated using ethanol-induced ulceration, and cold stress-induced ulceration. Notably, both extracts exhibited significant protection against ulcers, particularly at the highest dose of 400 mg/kg, when compared to the standard treatment.To substantiate the antiulcer potential of Phyllanthus niruri, we examined its capacity to scavenge free radicals through lipid peroxidation assays. The results revealed a noteworthy level of antioxidant activity in the extracts. This antioxidant property may be attributed to the presence of flavonoids and polyphenols within the extracts. In summary, our findings suggest that both hydroalcoholic and petroleum ether extracts obtained from the leaves of Phyllanthus niruri possess gastric ulcer-protective properties, making them promising candidates for further investigation and potential therapeutic application.