Diabetes associated with hyperglycemia majorly affecting the vital organs due to macro and micro-vascular complications. Dietary supplement contains polyphenols possesses promising antidiabetic properties that could be useful for glycemic control and to restrain the diabetic complications. In the present study the use of epigallocatechin gallate and resveratrol alone and in combination for the treatment of diabetes for 21 days and its complications were assessed using alloxan monohyderate as a inducer (140 mg/kg). Various biochemical markers were assessed such as plasma glucose, lipid profile, kidney function test, liver glycogen, body weight and histology of kidney. Epigallocatechin and resveratrol significantly ameliorate the elevated plasma glucose and retard the dyslipidemia. Furthermore; these polyphenols significantly control the altered kidney parameters and improves the liver glycogen content and body weight. Moreover; the co-treatment of Epigallocatechin–resveratrol with glimepiride significantly modulates the glomerular sclerosis owing to its antidiabetic potential. Use of dietary supplement in the management of diabetes and its complications would be an adjuvant therapy to control hyperglycemia induced vital organ damage.