Clinical pharmacologists have not been strikingly successful in advancing their knowledge to therapeutics. There remain areas of activity where the influence of the discipline has been less impressive, and where there are real opportunities for the future of the subject. We as pharmacologists, fail to translate the in-depth knowledge of pharmacology of the drugs into clinical practice. The influence of clinical pharmacologists to correct the deficiencies in clinical practice within their own institutions appears to be minimal. Pharmacologist can promote and ensure the safe, economic and efficient use of medicines to improve patient care. Pharmacology promotes the rational use of medications in humans by studying their restorative effect to amplify the drugs effect and reduce the side effects.