The effect of environmental climate factors on the formation of leaf pubescence in 15 stress-resistant wheat varieties selected based on previous experiments studied. The conditions of the two-year field experience in the Tashkent region, Uzbekistan, varied in terms of precipitation; the climate in 2021 was dry, and in 2022 it was humid with high humidity. The difference noted in the number and length of trichomes in relation to the changing climatic conditions of the varieties: a dry and very dry climate in 2021 and a rainy spring with increased humidity in 2022. It was observed that the contagion of the studied wheat varieties with yellow rust depends on climate change. There are some varieties that were nonresistant to rust disease in the irrigated plot during the dry period of the climate, but they showed moderate resistance in the water shortage plot, i.e., in non-irrigated conditions. A different correlation was determined within the studied conditions among the length, number of trichomes, and damage by yellow rust disease, and productivity.