Antibiotic resistance is a global health threat. In 2001, the World Health Organization (WHO) released a global strategic plan with the aim of controlling antibiotic resistance. During the subsequent year, a workshop found significant obstacles to the execution of the plan, such as inadequate health infrastructures, limited availability of reliable data, and a deficiency in the adoption of antibiotic stewardship (ABS) programs in medical curricula. In this article, we will examine the collaboration between physicians, nurses, and pharmacists in the field of antibiotic stewardship. Effective preservation of antibiotic efficacy necessitates the future prioritization of interprofessional and multidisciplinary collaboration among doctors, pharmacists, and nursing staff. This collaboration is crucial for adequately preparing healthcare professionals to address global healthcare challenges.